Current location:International Intervals news portal > world
Chinese scientists create mutant Ebola virus to skirt around biosafety rules
International Intervals news portal2024-05-07 14:40:00【world】3People have gathered around
IntroductionChinese scientists have engineered a virus with parts of Ebola in a lab that killed a group of hamst
Chinese scientists have engineered a virus with parts of Ebola in a lab that killed a group of hamsters.
A team of researchers at Hebei Medical University used a contagious disease of livestock and added a protein found in Ebola, which allows the virus to infect cells and spread throughout the human body.
The group of hamsters that received the lethal injection 'developed severe systemic diseases similar to those observed in human Ebola patients,' including multi-organ failure,' the study shared.
One particularly horrific symptom saw the infected hamsters develop secretions in their eyes, which impaired their vision and scabbed over the surface of the eyeballs
While the experiment may spark fears of another lab leak, the researchers say their goal was to find the right animal models that can safely mimic Ebola symptoms in a lab setting.
Chinese scientists have engineered virus to contain parts of Ebola (pictured) in a lab that killed a group of hamsters in just three days
A team of researchers at Hebei Medical University used a contagious disease of livestock and added a protein found in Ebola that allows it to infect cells and spread throughout the human body (stock)
The study suggested that infected hamsters could be a decent model for studying the spread and treatment of Ebola in the future.
Ebola needs to be handled in Biosafety Level 4 (BSL-4) facilities which are special high security laboratories, while many are only BLS-2.
To work around this in a lower security setting, scientists used a different virus called vesicular stomatitis virus (VSV), which they engineered to carry part of the Ebola virus that's called glycoprotein (GP) that plays a crucial role in helping the virus enter and infect cells of its host.
The infected hamsters developed secretions in their eyes, which impaired their vision and covered the surface of the eyeballs
The team studied five female and five male hamsters that were all three weeks old.
All female Syrian hamsters showed decreased rectal temperature and up to 18 percent weight loss - they all died between two and three days.
The five male hamsters lost 15 percent weight and succumbed to the disease at no later than three and a half days.
However, two male hamsters survived and gained 20 percent more weight than pre-infection.
The team harvested organs from the dead animals, finding the virus accumulated in the heart, liver, spleen, lung, kidney, stomach, intestines and brain tissues.
The highest levels were found in the liver and lowest in the brain.
'It is a sign that 3-week-old Syrian hamsters infected with VSV-EBOV/GP have the possibility of playing a role in the study of optic nerve disorders caused by EVD,' the team shared in the study, which was published in the Chinese journal Virologica Sinica.
The group of female hamsters also had multi-organ failure
The team concluded that the infected hamsters showed a rapid onset of symptoms, shock liver, systemic infection, and developed severe systemic diseases similar to those observed in human EBOV patients.
They also noted that the experiments provided a rapid preclinical evaluation of medical countermeasures against Ebola under BLS-2 conditions, concluding the study was a success.
EXCLUSIVEREAD MORE: Inside NIH virus lab in Montana - that has eerie ties to Wuhan
Photos and videos obtained exclusively by DailyMail.com show US government-funded researchers experimenting on animals at a controversial lab in Montana where risky virus research is carried out.
AdvertisementThe last major outbreak of the virus occurred from 2014 to 2016 in several West African countries was deadly, a report from the World Health Organization (WHO) said.
During those two years more than 28,600 people were reportedly infected, and about 11,300 died.
The virus spread from West Africa to Europe and even over to the United States.
'The surrogate virus and matched hamster EVD [Ebola virus disease] model will improve the security and economy of the research in the EBOV field,' the researchers wrote in the study.
Testing infectious viruses is necessary for breakthroughs in treatment and prevention.
But lab leaks happen, and these incidents could lead to the spread of to those outside of the lab.
Experts have confirmed that respiratory viruses – which are spared via coughing and sneezing – are more likely to spread widely through a population.
Data released this March revealed that lab leak incidents occur every year and included the release of controlled pathogens like tuberculosis and anthrax.
There are anywhere from 70 to 100 releases were recorded every year.
However Dr Richard Ebright, a chemical biologist at Rutgers University in New Jersey told DailyMail.com that its unlikely that a lab leak involving VSV would lead to widespread infection in the public.
'[It] will be imperative to verify that the novel chimeric virus does not infect and replicate in human cells, and does not pose risk of infectivity, transmissibility, and pathogenicity in humans, before proceeding with studies at biosafety level 2,' he said.
Address of this article:http://barbados.shellye-mcdaniel.com/news-47c199848.html
Very good!(73333)
Related articles
- Polish prosecutors open investigation after judge flees to autocratic Belarus
- Rivalries on tap with Barcelona
- Closing prices for crude oil, gold and other commodities
- San Francisco mayor announces the city will receive pandas from China
- Woman, 62, is left baffled as she turns up to a hospital scan only to be told she's already dead
- Jets beat Canucks 4
- Netflix adaptation of The Talented Mr. Ripley fuels tourism to tiny Italian town
- Rivalries on tap with Barcelona
- DJ Chark Jr. signs with the Los Angeles Chargers
- Rivalries on tap with Barcelona
Popular articles
Recommended
Late Baldé header steals dramatic 4
Laborers and street vendors in Mali find no respite as deadly heat wave surges through West Africa
Kraken outlast Wild 4
Dramatic moment lorry on the M56 is engulfed by flames: HGV is destroyed by raging inferno
Boeing calls off Starliner launch due to rocket issue
Teenager is charged with terrorism offenses in stabbings of bishop and priest at Sydney church
Andy Murray back on practice court after confirming no surgery for ankle injury
Maurizio Cattalan, Zoe Soldana collaborate in iconoclastic Vatican exhibition inside women’s prison
Links
- Senior CPC Officials Submit Work Reports to CPC Central Committee, Xi
- De Gaulle role in Sino
- Quan, Wang add two golds for China at diving World Cup in Berlin
- De Gaulle role in Sino
- Ruling sparks debate on AI technology
- Xi Jinping's Economic Thought Steers China Toward Modernity
- Books on Study, Practice of Xi Jinping's Economic Thought Published
- Cherry blossom in Yuyuantan Park, with the Central Television Tower as background
- Beijing slams Washington for spreading false info
- US, Arab states at odds on truce